期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 9, 页码 1461-1464出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00083b
关键词
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资金
- National Natural Science Foundation of China [21372204]
- Program for Innovative Research Team of Zhejiang Sci-Tech University [13060052-Y]
- Zhejiang Sci-Tech University 521 project
BF3 center dot Et2O promoted metal-free denitrogenative transannulation of N-sulfonyl-1,2,3-triazole was reported. Rather than transition metals, BF3 center dot Et2O was employed for the first time to promote the formation of alpha-diazoimines from N-sulfonyl-1,2,3-triazoles in nitriles, leading to the synthesis of various imidazoles. The protocol tolerates a broad range of functional groups and could also be applied to the late-stage modification of bioactive molecules, demonstrating the potential of this protocol in organic synthesis. A plausible mechanism was proposed.
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