期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 18, 页码 3419-3427出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00581h
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资金
- DST-SERB, India [EMR/2014/000978]
- SERB-NPDF [PDF/2016/001967]
A ruthenium(II) catalyzed remote C-5 alkylation of the quinoline ring of N-(quinolin-8-yl)benzamides with alkyl bromides via C-H bond activation is described. Various substituted N-(quinolin-8-yl)benzamides reacted with tertiary or secondary or primary alkyl bromides giving the alkylated products in good to moderate yields. Herein, the ruthenium catalyzed remote C-5 alkylation is effected via aromatic C-H bond activation as a key step. It has been proved by the deuterium labelling studies and mechanistic investigations.
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