期刊
ORAL ONCOLOGY
卷 78, 期 -, 页码 126-136出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2018.01.011
关键词
Oral cancer; Oral squamous cell carcinoma; Podoplanin; Signal transduction; Cancer therapy; Biomarkers; Contact normalization; Chemotherapy; CLEC-2
资金
- Osteopathic Heritage Foundation
- Northarvest Bean Growers Association
- New Jersey Health Foundation
- Sentrimed
- Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- MEXT of Japan
Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemotherapeutic treatments are needed to more effectively combat oral cancer. The transmembrane receptor podoplanin (PDPN) has emerged as a functionally relevant oral cancer biomarker and chemotherapeutic target. PDPN expression promotes tumor cell migration leading to oral cancer invasion and metastasis. Here, we describe the role of PDPN in oral squamous cell carcinoma progression, and how it may be exploited to prevent and treat oral cancer.
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