期刊
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
卷 2, 期 7, 页码 -出版社
WILEY
DOI: 10.1038/psp.2013.26
关键词
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This tutorial describes the development of a population pharmacokinetic (Pop PK) analysis guidance within Pfizer, which strives for improved consistency and efficiency, and a more systematic approach to model building. General recommendations from the Pfizer internal guidance and a suggested workflow for Pop PK model building are discussed. A description is also provided for mechanisms by which conflicting opinions were captured and resolved across the organization to arrive at the final guidance.
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