期刊
ONCOLOGY REPORTS
卷 39, 期 3, 页码 1432-1440出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2018.6216
关键词
TRPV6; pancreatic cancer; expression; progression
类别
资金
- Chinese National Science Foundation [81672835]
In this study, we aimed to clarify the expression and biological functions of TRPV6 in human pancreatic cancer (PC) tissue and pancreatic cancer (PC) cell lines. TRPV6 was up-regulated in the primary cancer tissues from pancreatic cancer (PC) patients. TRPV6 may regulate multiple proteins related to apoptosis, cell cycle and metastasis pathways. Silencing TRPV6 significantly inhibited invasion, proliferation and migration and induced apoptosis and cell cycle arrest. TRPV6 plays a promising role of an oncogene in pancreatic carcinogenesis and represents the new potential biomarker for PC.
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