期刊
ONCOLOGY REPORTS
卷 40, 期 2, 页码 767-774出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2018.6456
关键词
microRNA-152; osteosarcoma; DKK1; Wnt/beta-catenin
类别
The function of microRNA-152 for a cohort of patients with osteosarcoma and the influence on cell growth of osteosarcoma were studied. The expression of microRNA-152 was downregulated in patients with osteosarcoma. The downregulation of microRNA-152 promotes cell proliferation, decreases apoptosis, and suppresses LDH activity, caspase-3/9 activities and Bax/Bcl-2 and p53 protein expression levels of osteosarcoma through activation of the Wnt/-catenin signaling pathway by targeting DKK1. Whereas, overexpression of microRNA-152 targets DKK1 to inhibit cell proliferation, induce apoptosis, and promote LDH activity, caspase-3/9 activities and Bax/Bcl-2 and p53 protein expression levels of osteosarcoma through inactivation of the Wnt/-catenin signaling pathway. The promotion of DKK1 reversed the anticancer function of microRNA-152 overexpression through Wnt/-catenin signaling pathway. We demonstrated that microRNA-152 inhibits cell proliferation of osteosarcoma through DKK1 by directly targeting Wnt/-catenin signaling pathway.
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