期刊
ONCOGENE
卷 37, 期 37, 页码 5037-5053出版社
SPRINGERNATURE
DOI: 10.1038/s41388-018-0175-6
关键词
-
资金
- URMC Urology Department Research fund
- George Whipple Professorship Endowment
Recent studies indicated that the estrogen receptor beta (ER beta) could affect the progression of prostate and bladder tumors, however, its roles in the renal cell carcinoma (RCC), remain to be elucidated. Here, we provide clinical evidence that ER beta expression is correlated in a negative manner with the overall survival/disease-free survival in RCC patients. Mechanism dissection revealed that targeting ER beta with ER beta-shRNA and stimulating the transactivation of ER beta with 17 beta-estradiol or environmental endocrine disrupting chemicals, all resulted in altering the lncRNA HOTAIR expression. The ER beta-modulated HOTAIR is able to function via antagonizing several microRNAs, including miR-138, miR-200c, miR-204, or miR-217 to impact various oncogenes, including ADAM9, CCND2, EZH2, VEGFA, VIM, ZEB1, and ZEB2, to promote RCC proliferation and invasion. Together, the identification of the ER beta-HOTAIR axis may provide us new biomarkers and/or therapeutic targets to better suppress RCC progression in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据