期刊
OBESITY
卷 26, 期 7, 页码 1234-1241出版社
WILEY
DOI: 10.1002/oby.22208
关键词
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资金
- National Institutes of Health, National Heart, Lung, and Blood Institute [HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01HL088451]
- National Center for Advancing Translational Sciences [UL1-TR-000040, UL1-TR-001079]
ObjectiveThis study examined the associations of muscle area and radiodensity with adiponectin and leptin. MethodsA total of 1,944 participants who enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin-6, C-reactive protein, and resistin. ResultsThe mean age and BMI of participants were 64.7 years and 28.1 kg/m(2) and 49% were female. With adjustment for age, gender, race/ethnicity, traditional cardiovascular disease risk factors, inflammatory biomarkers, physical activity, and sedentary behavior, a 1-SD increment in total abdominal, stability, and locomotor muscle area was associated with a 19%, 17%, and 12% lower adiponectin level, respectively (P<0.01 for all) but not leptin (P>0.05). Muscle radiodensity was more robustly associated with adiponectin and leptin in the multivariable linear regression models. That is, with full adjustment for all covariates, a 1-SD increment in total abdominal, stability, and locomotor muscle radiodensity was associated with a 31%, 31%, and 18% lower adiponectin level (P<0.01 for all) and a 6.7%, 4.6%, and 8.1% higher leptin level (P<0.05 for all), respectively. ConclusionsThe data suggest that increases in muscle area and radiodensity may have positive impacts on chronic inflammation and, in turn, reduce the risk of cardiometabolic disease.
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