期刊
OBESITY
卷 26, 期 7, 页码 1203-1210出版社
WILEY
DOI: 10.1002/oby.22203
关键词
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资金
- Commission of the European Community [QLRT-2001-00389, QLK1-CT-2002-30582]
- Sixth Framework Program [007036]
- European Union (EU) Seventh Framework Program, project EarlyNutrition [289346]
- EU H2020 project PHC-DynaHealth [633595]
- European Research Council Advanced Grant ERC-AdG META-GROWTH [322605]
- EU Commission
- European Research Council (ERC) [322605] Funding Source: European Research Council (ERC)
ObjectiveThe objective of this study was to investigate the effect of lower protein (LP) versus higher protein (HP) content in infant formula on body composition from 3 months to 6 years. MethodsIn a multicenter, double-blind European trial, healthy infants (N=1,090) were randomly assigned to different protein content formulas (upper [HP] and lower [LP] limits of the European Union regulations in 2001) during the first year; breastfed infants (N=588) were recruited for reference values. Weight, height, and triceps and subscapular skinfold (SF) thickness were measured repeatedly (N=650 at 6 years), and body composition was estimated (Slaughter). The 99th percentile of fat mass index reference data were used to assess excess body fat at 6 years. ResultsAt 2 and 6 years, the study observed greater sum of SFs ( 2 years: 0.5 mm, P=0.026, 6 years: 0.6 mm, P=0.045), fat mass index ( 2 years: 0.12 kg/m(2), P=0.008, 6 years: 0.15 kg/m(2), P=0.011), and fat-free mass index ( 2 years: 0.17 kg/m(2), P=0.003, 6 years: 0.18 kg/m(2), P=0.010) in the HP group compared with the LP group. At 6 years, the HP group had a twofold higher risk than the LP group for excess body fat (adjusted odds ratio: 2.13, P=0.019). ConclusionsInfant formula with HP levels induced greater fat mass in children from 2 to 6 years. Lowering the protein content of infant formula may result in a healthier body composition in early childhood.
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