期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 28, 期 6, 页码 565-574出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2018.03.001
关键词
Metabolic syndrome; Obesity; Probiotic; Yogurt
资金
- Shiraz University of Medical Sciences, Shiraz, Iran [95-11455]
Background and Aims: Obesity is a complex and multifaceted condition. Thus, functional foods need investigation as novel adjunct treatments for obesity. The objective was to determine the effects of daily consumption of a fortified yogurt (FY) on weight loss in over-weight and obese patients with metabolic syndrome on a caloric-restricted diet. Methods and Results: This was a randomized, double-blind, 10-week study. Participants were randomly allocated to two groups receiving either two servings (2 x 250 g)/day of FY with whey protein, calcium, vitamin D, prebiotic fibre and probiotic cultures (n = 44) or a low-fat plain yogurt (PY) (n = 43). All participants were put on a calorie-restricted diet throughout the 10-week study. Body composition and biochemical indices were assessed before and after the intervention. Body mass decreased by 4.3 +/- 1.9 kg and 5.1 +/- 3.0 kg in the PY and FY groups, respectively, following the 10-week intervention. Compared to PY, consumption of FY resulted in a significant reduction in body fat mass (FM) (p = 0.023), body fat percentage (p = 0.028), waist circumference (p = 0.002), homoeostasis model of assessment-insulin resistance (HOMA-IR) (p = 0.025), triglyceride concentration (p = 0.003), and a significant increase in total 25-hydroxyvitamin D (25(OH)D) concentration (p < 0.001), high density lipoprotein-cholesterol (HDL-C) (p = 0.009) and quantitative insulin sensitivity check index (QUICKI) (0.022). Participants consuming the FY lost less fat-free mass (FFM) compared to the PY group (Delta = -0.9 +/- 3.5 kg vs. Delta = -2.0 +/- 2.7 kg; p = 0.025). Conclusions: Consuming FY for 10-weeks improved body composition and metabolic parameters, while on a caloric-restricted diet. Further research is needed to elucidate whether FY can be used as a preventative strategy for metabolic syndrome in obese persons. (C) 2018 Published by Elsevier B.V. on behalf of The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
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