期刊
NUTRITION
卷 54, 期 -, 页码 165-172出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2018.03.056
关键词
5-fluorouracil; Lactic acid bacteria; Mucositis; Probiotic; Riboflavin
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas [PIP0697]
- Agencia Nacional de Promocion Cientifica y Tecnologica [2554, 2859, 0301]
Objectives: Intestinal mucositis (IM) is a local inflammatory response that causes alterations of the intestinal structure that in turn affect nutrient absorption and a side effect that is commonly associated with cancer treatments. Lactobacillus plantarum CRL2130 is a riboflavin-overproducing strain that has previously been shown to provide antiinflammatory properties. The objective of this study was to evaluate the effects of this riboflavin-producing strain in a chemically induced murine mucositis model. Methods: Mucositis was induced by daily injections of 5-fluororacil (5-FU) after which mice were either given L. plantarum CRL2130, CRL725 (strain from which CRL2130 was derived that does not overproduce riboflavin), or commercial riboflavin twice daily during 6 d of chemotherapy agent injections. The effect of the strains and riboflavin was also evaluated in vitro using Caco-2 intestinal cancer cell cultures to determine if they interfere with 5-FU's anticancer activity. Results: The administration of L plantarum CRL2130 significantly attenuated the pathologic changes induced by 5-FU in mice such as body weight loss, diarrhea, shortening of villus height, increases in proinflammatory cytokine concentrations, and elevated production of interleukin 10. In vitro assays using Caco-2 cells showed that the effectiveness of 5-FU was not affected by L. plantarum CRL2130 and that this strain exerted an inhibitory mechanism against oxidative stress. Conclusions: These results indicate that the riboflavin-overproducing strain L plantarum CRL2130 could be useful to prevent mucositis during cancer treatments and would not affect the primary treatment. (C) 2018 Elsevier Inc. All rights reserved.
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