期刊
NUTRITION
卷 46, 期 -, 页码 97-102出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2017.09.003
关键词
Age; Anthropometry; Mortality; Obesity; Sarcopenia
资金
- Kuakini Medical Center
- John A. Hartford Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii
- National Institutes of Health (NIH) from the National Institute on Aging [N01-AG-4-2149, U01 AG019349, R01 AG027060, R01 AG038707]
- National Institutes of Health (NIH) from the National Heart, Lung, and Blood Institute [N01-HC-05102]
- Hawaii Community Foundation [2004-0463]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24300239]
- Grants-in-Aid for Scientific Research [15H03099] Funding Source: KAKEN
Objective: The aim of this study was to investigate the association between anthropometric measurements of sarcopenic obesity and all-cause mortality. Methods: The study included 2309 Japanese-American men ages 71 to 93 y. Mortality data were available for up to 24 y of follow-up. Sarcopenic obesity defined by three patterns of obesity indexes (body mass index [BMI], percent body fat [%BF] and waist circumference [WC]) and skeletal muscle index estimated by anthropometric measurements. Results: Of the 2309 participants, 2210 deaths were reported during the mean follow-up period of 11.7 y. Risk for death was significantly increased with sarcopenia after adjusting for baseline age, lifestyle variables, hypertension, diabetes, and cognitive scores (hazard ratio [HR], 1.26; 95% confidence interval [CI], 1.15-1.38). Risk for death was significantly decreased with obesity using WC and %BF to define obesity, but not BMI. Risk for death also was significantly increased in the sarcopenia group compared with the optimal group, regardless of which pattern of obesity indexes (BMI, %BF, and WC) was used. Risk for death was significantly increased in sarcopenic obesity defined by WC (HR, 1.19; 95% CI, 1.02-1.38), borderline in the BMI-defined group, and not significant in the %BF-defined group. Conclusion: All-cause mortality was increased in men with sarcopenic obesity defined by WC, but not BMI and %BF. Sarcopenia was a stronger predictor of all-cause mortality in this cohort >70 y of age. These results suggest that anthropometric definitions for sarcopenia and sarcopenic obesity are clinically useful as a predictor of all-cause mortality. (C) 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgilicensesiby-nc-nc1/4.0/).
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