期刊
RADIOCHIMICA ACTA
卷 101, 期 6, 页码 359-366出版社
OLDENBOURG VERLAG
DOI: 10.1524/ract.2013.2047
关键词
Spectrophotometric titration; Actinide decorporation; Hydroxypyridinonate ligands; UO2 complexes; Th complexes
资金
- National Institutes of Health from the National Institute of Allergy and Infectious Diseases [1RC2AI087604-01, 5RC2AI087604-02]
- E. O. Lawrence Berkeley National Laboratory, a U.S. Department of Energy Laboratory [DE-AC02-05CH11231]
Solution thermodynamic studies were performed to characterize the coordination of U(VI) and Th(IV) by the multidentate hydroxypyridinonate chelating agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Species distribution and conditional stability pM profiles were calculated based on the determined formation constants, showing that both ligands form extremely stable uranyl and thorium complexes in solution. At physiological pH, the formation of 1:1 ligand : uranyl complexes is favored for both ligands, while a 2:1 ligand : thorium complex is predominant with the tetradentate 5-LIO(Me-3,2-HOPO). Comparisons with functionally similar bidentate ligands as well as with the common actinide chelator diethylenetriamine pentaacetic acid emphasized the superior affinity for U(VI) and Th(IV) of both experimental compounds over a wide pH range. These analytical results corroborate the in vivo chelation efficacy of 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) and validate their selection for further development as therapeutic actinide decorporation agents.
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