期刊
JOURNAL OF CHEMICAL SCIENCES
卷 125, 期 3, 页码 525-530出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-013-0421-y
关键词
Multicomponent reactions (MCRs); pyrazole; naphthols
资金
- University Grants Commision (UGC), New Delhi, India
Libraries of 2-amino-4H-chromenes, were efficiently synthesized via one-pot, three-component reactions of 5-chloro-3-methyl-1-aryl-4,5-dihydro-1H-pyrazole-4-carbaldehyde (1a-c), 2-naphthols (2a-f) and malononitrile in the presence of catalytic amount of ammonium acetate under microwave irradiation. The protocol offers rapid synthesis of structurally diverse 2-amino-4H-chromenes for biological screening. All the synthesized compounds were evaluated for their antimicrobial activity, and several compounds exhibited moderate to potent antimicrobial activity.
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