Role of Adipose Tissue in Metabolic System Disorders Adipose Tissue is the Initiator of Metabolic Diseases

The pathogenesis of obesity-induced metabolic syndrome is due to the dysfunction of the metabolic system. The metabolic system is composed of different components including energetic molecules, endocrine system and metabolically active tissues like adipose tissue (AT), skeletal muscles and liver. AT plays a significant role in the regulation of metabolic system components. Evaluation of the functionality of this system is one of the main steps in the diagnosis and determination of the severity of metabolic disorders as well as evaluation of the treatment process of patients with metabolic disorders. In this review, we have aimed to highlight the physiological role of AT as one of the major determinants in the regulation of the metabolic system. Subsequently, the main parameters for evaluation of energy metabolic system functionality components are introduced.