期刊
NATURE REVIEWS IMMUNOLOGY
卷 13, 期 8, 页码 551-565出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3479
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- Swiss National Science Foundation [PP00P3_139120/1]
- US National Institute of Allergy and Infectious Diseases [AI095396, AI08972]
- Swiss National Science Foundation (SNF) [PP00P3_139120] Funding Source: Swiss National Science Foundation (SNF)
Recognizing the presence of invading pathogens is key to mounting an effective innate immune response. Mammalian cells express different classes of germline-encoded pattern recognition receptors that monitor the extracellular and intracellular compartments of host cells for signs of infection and that activate several conserved signalling pathways. An efficient immune response often requires the sequential detection of a pathogen by different receptors in different subcellular compartments, which results in a complex interplay of downstream signalling pathways. In this Review, we discuss the recent identification of previously unknown pattern recognition receptors and how they complement the repertoire of established receptors.
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