期刊
NEW JOURNAL OF CHEMISTRY
卷 42, 期 5, 页码 3526-3533出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nj04960a
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资金
- Natural Science Foundation of Jiangsu Province of China [BK20170834]
- Fundamental Research Funds for the Central Universities [30917011313]
- National Natural Science Foundation of China [21305066]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A cationic cyclodextrin (CD) clicked bilayer chiral stationary phase (CSP) was developed via click chemistry for chiral separations in multimode high-performance chromatography (HPLC). The versatility of this new CSP was evaluated using 17 model racemic pairs including aromatic alcohols, flavonoids and isoxazoline enantiomers in both reversed-phase (RP) and normal-phase (NP) HPLC. The CD functionality-enhanced chiral selectivity was elucidated in different elution modes. Higher chiral resolutions were shown in the RP-elution mode due to the inclusion complexation in comparison to the NP-elution mode. The highest chiral resolution of 4.40 was achieved for 4ClPh-OPr, with 12 racemic pairs baseline separated in RP-HPLC. The addition of organic modifiers in mobile phases plays an important role in optimizing the enantioselectivities of the cationic CD bilayer CSP in NP-HPLC.
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