期刊
NEW JOURNAL OF CHEMISTRY
卷 42, 期 7, 页码 5237-5242出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nj04633b
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The Fisher esterification reaction has been exploited for linking a peptide (chlorotoxin) onto the surface of nanocellulose using a Bronsted acid ionic liquid both as a solvent and a catalyst. Indeed, cellulose nanocrystals were functionalized with the peptide thanks to a mild, one-step and organic solvent-free reaction. The obtained nanocellulose showed excellent properties in terms of biocompatibility and internalization in the U87MG glioblastoma cell line, thus demonstrating the possible use of this material as a novel drug delivery carrier.
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