期刊
NEUROTHERAPEUTICS
卷 15, 期 1, 页码 156-175出版社
SPRINGER
DOI: 10.1007/s13311-017-0593-0
关键词
S-Adenosyl-methionine; Transmethylation; Pathway; Psychiatric disease; Neurodegenerative disease
资金
- National Natural Science Foundation of China [81501170]
- Zenith Fellows Award of Alzheimer's Association
- National Institutes of Health [R21NS077079-01A1, 1R01AG056614-01]
- [5R01MH102279-03]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS077079, R21NS059434, R21NS064853] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG056614] Funding Source: NIH RePORTER
S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and the disturbance in transmethylation pathways. Also included in this review are the present-day applications of SAMe in the treatment in these diseases in each age group.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据