期刊
NEUROSCIENCE RESEARCH
卷 126, 期 -, 页码 39-43出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.10.004
关键词
Spinal cord injury; Astrocytes; Glial scar; Axonal regeneration; Laser microdissection
资金
- Ministry of Education, Science, Sports and Culture of Japan [16H05450, 16K15668]
After traumatic injuries of the central nervous system (CNS), including spinal cord injury (SCI), astrocytes surrounding the lesion become reactive and typically undergo hypertrophy and process extension. These reactive astrocytes migrate centripetally to the lesion epicenter and aid in the tissue repair process, however, they eventually become scar-forming astrocytes and form a glial scar which produces axonal growth inhibitors and prevents axonal regeneration. This sequential phenotypic change has long been considered to be unidirectional and irreversible; thus glial scarring is one of the main causes of the limited regenerative capability of the CNS. We recently demonstrated that the process of glial scar formation is regulated by environmental cues, such as fibrotic extracellular matrix material. In this review, we discuss the role and mechanism underlying glial scar formation after SCI as well as plasticity of astrogliosis, which helps to foster axonal regeneration and functional recovery after CNS injury. (c) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据