期刊
NEUROSCIENCE RESEARCH
卷 129, 期 -, 页码 40-46出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2018.02.002
关键词
Entorhinal cortex; Hippocampus; Gamma oscillations; Alzheimer's disease
资金
- PRESTO Grant from Japan Science and Technology Agency [JPMJPR1681]
- Fay-Frank Seed Grant from Brain Research Foundation [BRFSG-2017-04]
- Alzheimer's Association Research Grant [AARG-17-532932]
- Whitehall Foundation Research Grant [2017-08-01]
- NIH [R01-AG056303, RF1-AG055524, P50-AG016573, R01-NS083801]
Gamma oscillations that occur within the entorhinal cortex-hippocampal circuitry play important roles in the formation and retrieval of memory in healthy brains. Recent studies report that gamma oscillations are impaired in the entorhinal-hippocampal circuit of Alzheimer's disease (AD) patients and AD animal models. Here we review the latest advancements in studies of entorhinal-hippocampal gamma oscillations in healthy memory and dementia. This review is especially salient for readers in Alzheimer's research field not familiar with in vivo electrophysiology. Recent studies have begun to show a causal link between gamma oscillations and AD pathology, suggesting that gamma oscillations may even offer a plausible future therapeutic target. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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