期刊
NEUROSCIENCE RESEARCH
卷 128, 期 -, 页码 1-13出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.10.009
关键词
Common marmoset; High throughput ISH analysis; Digital atlas; Comparative analysis; Mental disorder
资金
- BSI-NI(BSI-Neuroinformatics) project
- RIKEN Brain Science Institute (TS)
- Funding Program for World-leading Innovative R&D on Science and Technology
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [16H06531, 16H04849] Funding Source: KAKEN
Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas.bminds.brain. riken.jp/) provides a whole brain gene expression atlas in the common marmoset. We employ in situ hybridization (ISH) to systematically analyze gene expression in neonate marmoset brains, which allows us to compare expression with other model animals such as mouse. We anticipate that these data will provide sufficient information to develop tools that enable us to reveal marmoset brain structure, function, cellular and molecular organization for primate brain research. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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