期刊
NEUROSCIENCE LETTERS
卷 673, 期 -, 页码 132-135出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2018.03.010
关键词
Calcineurin; Calmodulin; Sphingosylphosphorylcholine; Psychosine; Glucosylsphingosine
资金
- Research Grant of Hyogo Science and Technology Association [28014]
- Grants-in-Aid for Scientific Research [26430071, 17H03666, 17KT0024, 17K07110] Funding Source: KAKEN
Neurons have well-developed membrane microdomains called rafts that are recovered as a detergent-resistant membrane microdomain fraction (DRM). NAP-22 is one of the major protein components of neuronal DRM. In a previous study, we showed that DRM-derived NAP-22 binds ganglioside and the inhibitory effect of ganglioside to calcineurin (CaN), a neuron-enriched calmodulin-regulated phosphoprotein phosphatase. Considering the important roles of CaN in neurons, identification of other cellular regulators of CaN could be a good clue to understand the molecular background of neuronal function. In this study, we screened the effect of several membrane lipid-derived molecules on the CaN activity and found sphingosine and some sphingosine-derived metabolites such as sphingosylphosphorylcholine, galactosylsphingosine (psychosine), and glucosylsphingosine, have inhibitory effect on CaN through the interaction with calmodulin.
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