期刊
HORMONES AND BEHAVIOR
卷 73, 期 -, 页码 15-22出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2015.05.009
关键词
Body weight; Brain-gut axis; Food intake; Hypothalamus; Satiation; Satiety; Somatostatin receptor; Stress; Water intake
资金
- NIH Center [DK-41301]
- German Research Foundation [STE 1765/3-1]
- Charite University [UFF 88-226-168]
Somatostatin was discovered four decades ago as hypothalamic factor inhibiting growth hormone release. Subsequently, somatostatin was found to be widely distributed throughout the brain and to exert pleiotropic actions via interaction with five somatostatin receptors (sst(1-5)) that are also widely expressed throughout the brain. Interestingly, in contrast to the predominantly inhibitory actions of peripheral somatostatin, the activation of brain sst(2) signaling by intracerebroventricular injection of stable somatostatin agonists potently stimulates food intake and independently, drinking behavior in rodents. The orexigenic response involves downstream orexin-1, neuropeptide Y-1 and mu receptor signaling while the dipsogenic effect is mediated through the activation of the brain angiotensin 1 receptor. Brain sst2 activation is part of mechanisms underlying the stimulation of feeding and more prominently water intake in the dark phase and is able to counteract the anorexic response to visceral stressors. Published by Elsevier Inc.
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