期刊
NEUROSCIENCE LETTERS
卷 672, 期 -, 页码 34-39出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2018.02.018
关键词
L-Tetrahydropalmatine; Methamphetamine; Memory impairment
资金
- National Natural Science Foundation of China [81430048]
- Education Department of Shaanxi Province [17JK0657]
Methamphetamine (METH) administration results in addiction and memory impairment. Previous studies have suggested that levo-tetrahydropalmatine (L-THP), an alkaloid purified from the Chinese herb Corydalis, attenuates the behavioral changes induced by METH. Therefore, in this study, we explored whether L-THP could also protect against the METH-induced memory impairment examined using the Morris water maze (MWM). We found that low dose of METH (1.0 mg/kg) treated for 20 consecutive days prior to the MWM experiment impaired spatial memory retention but not acquisition in mice. In addition, high dose of METH (10.0 mg/kg) treated during the spatial learning phase for five consecutive days impaired both the acquisition and retention of spatial memory. Moreover, both of these impairments induced by METH were reversed by L-THP treatment, indicating a potential protective role of L-THP in METH use.
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