期刊
NEUROSCIENCE LETTERS
卷 688, 期 -, 页码 58-61出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2018.02.003
关键词
Autism spectrum disorder; Cerebral cortex; Cerebellum; Long-term depression; Synaptic pruning
A puzzling observation in the study of autism spectrum disorder (ASD) in mouse models has been the deregulation of long-term synaptic depression (LTD), a form of experience-dependent synaptic plasticity, across brain areas and across syndromic and non-syndromic forms of autism. This review attempts to approach this phenomenon from a largely, but not exclusively, cerebellar perspective. Three potential consequences of LTD deregulation are discussed that are relevant for ASD phenotypes: resulting impairment of proper developmental synaptic pruning, impairment of motor coordination and motor learning, and impairment of the processing of sensory input.
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