期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 90, 期 -, 页码 84-103出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.03.027
关键词
Cortico-cardiac interplay; Sleep; Autonomic nervous system; Central nervous system; Heart rate variability; Baroreflex; Sympathetic; Vagal; Electroencephalography; Electrocardiography
资金
- National Institutes of Health (NIH) [AA021696, HL103688, AA020565, AA024841]
- National Health and Medical Research Council (NHMRC) of Australia [1027076]
Sleep is characterized by coordinated cortical and cardiac oscillations reflecting communication between the central (CNS) and autonomic (ANS) nervous systems. Here, we review fluctuations in ANS activity in association with CNS-defined sleep stages and cycles, and with phasic cortical events during sleep (e.g., arousals, K-complexes). Recent novel analytic methods reveal a dynamic organization of integrated physiological networks during sleep and indicate how multiple factors (e.g., sleep structure, age, sleep disorders) affect CNS-ANS coupling. However, these data are mostly correlational and there is a lack of clarity of the underlying physiology, making it challenging to interpret causality and direction of coupling. Experimental manipulations (e.g., evoking K-complexes or arousals) provide information on the precise temporal sequence of cortical-cardiac activity, and are useful for investigating physiological pathways underlying CNS-ANS coupling. With the emergence of new analytical approaches and a renewed interest in ANS and CNS communication during sleep, future work may reveal novel insights into sleep and cardiovascular interactions during health and disease, in which coupling could be adversely impacted.
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