期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 85, 期 -, 页码 65-80出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2017.09.004
关键词
Hippocampus; Entorhinal cortex; Memory; Resonance; Grid cells; Place cells; Behaving mice; Anxiety; Speed; Optogenetics
资金
- NIH [R01 MH60013, R01 MH61492]
- Office of Naval Research MURI [N00014-16-1-2832]
- Human Frontier Science Program (HFSP) [RGY0076/2012]
- Deutsche Forschungsgemeinschaft (DFG)
- German-Israeli Foundation for Scientific Research and Development (GIF) [I-1326-421.13/2015]
- Biotechnology and Biological Sciences Research Council [BB/G01342X/1, BB/G01342X/2, BB/M008975/1]
- ERC ('DEVSPACE')
- Royal Society, UK [UF100746]
- Deutsche Forschungsgemeinschaft [Exc 257 NeuroCure]
- Deutsche Forschungsgemeinschaft (Priority Program 1665) [1799/1-1(2)]
- Biotechnology and Biological Sciences Research Council [BB/G01342X/2, BB/M008975/1, BB/G01342X/1] Funding Source: researchfish
- Medical Research Council [MR/N026012/1] Funding Source: researchfish
- Royal Society [UF100746] Funding Source: Royal Society
- BBSRC [BB/M008975/1, BB/G01342X/1, BB/G01342X/2] Funding Source: UKRI
- MRC [MR/N026012/1] Funding Source: UKRI
The theta oscillation (5-10 Hz) is a prominent behavior-specific brain rhythm. This review summarizes studies showing the multifaceted role of theta rhythm in cognitive functions, including spatial coding, time coding and memory, exploratory locomotion and anxiety-related behaviors. We describe how activity of hippocampal theta rhythm generators - medial septum, nucleus incertus and entorhinal cortex, links theta with specific behaviors. We review evidence for funtions of the theta-rhythmic signaling to subcortical targets, including lateral septtun. Further, we describe functional associations of theta oscillation properties - phase, frequency and amplitude - with memory, locomotion and anxiety, and outline how manipulations of these features, using optogenetics or pharmacology, affect associative and innate behaviors. We discuss work linking cognition to the slope of the theta frequency to running speed regression, and emotion-sensitivity (anxiolysis) to its y-intercept. Finally, we describe parallel emergence of theta oscillations, theta-mediated neuronal activity and behaviors during development. This review highlights a complex interplay of neuronal circuits and synchronization features, which enables an adaptive regulation of multiple behaviors by theta-rhythmic signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据