期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 90, 期 -, 页码 231-246出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2018.04.016
关键词
Impulsive aggression; Response inhibition; ADHD; DBDs; fMRI; sMRI; Prefrontal cortex; Cingulate cortex; Paralimbic system; Control; Top-Down; Emotional salience
资金
- International Research Training Group, Neuroscience of Modulating Aggression and Impulsivity in Psychopathology of the German Research Foundation (DFG) [IRTG-2150]
Background: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. Aims and Methods: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder -specific and shared IA and RI aberrant neural mechanisms. Results: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity. Conclusion: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.
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