期刊
NEUROPHARMACOLOGY
卷 136, 期 -, 页码 307-316出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2017.12.025
关键词
Neurodegeneration; Neuroinflammation; Metabolism; Leptin; Ghrelin
资金
- European Foundation for the Study of Diabetes/Juvenile Diabetes Research Foundation/Lilly program 2015
- National Multiple Sclerosis Society NMSS [PP-1606-24687]
- Fondazione Italiana Sclerosi Multipla FISM [2016/R/10, 2016/R/18]
- Italian Space Agency (ASI) [2014-033-R.O]
Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin. This article is part of the Special Issue entitled 'Metabolic Impairment as Risk Factors for Neurodegenerative Disorders. (C) 2017 Elsevier Ltd. All rights reserved.
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