期刊
NEURON
卷 98, 期 1, 页码 179-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.02.023
关键词
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资金
- Wellcome Trust [096436/B/11/Z]
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [U42OD012210] Funding Source: NIH RePORTER
To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of horizontal rotation. Behavioral and theoretical experiments indicate that these inputs, distributed over a network of 100 L6 neurons, provide both a reliable estimate and, therefore, physiological separation of head-velocity signals. During head rotation in the presence of visual stimuli, L6 neurons exhibit postsynaptic responses that approximate the arithmetic sum of the vestibular and visual-motion response. Functional input mapping reveals that these internal motion signals arrive into L6 via a direct projection from the retrosplenial cortex. We therefore propose that visual-motion processing in V1 L6 is multisensory and contextually dependent on the motion status of the animal's head.
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