期刊
NEURON
卷 99, 期 2, 页码 404-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.06.022
关键词
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资金
- Kjell and Marta Beijers Foundation [KDB 943/14]
- Swedish Research Council [2015-02395]
- Swedish Brain Foundation [FO2013-0139]
- Hallsten Foundation [FO2011-0280]
- Swedish Foundation for International Cooperation in Research and Higher Education (STINT) [BR2017-7095]
- Olle Engkvist Byggmastare Foundation [2016/173]
- Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES) [001/12]
- Brazilian National Council of Technological and Scientific Development (CNPq) [306146/2015-0]
- Swedish Research Council [2015-02395] Funding Source: Swedish Research Council
Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor alpha 2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLM alpha 2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLM alpha 2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLM alpha 2 cell activation inhibits fear-related memories and that OLM alpha 2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLM alpha 2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.
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