期刊
NEURON
卷 97, 期 4, 页码 940-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.01.032
关键词
-
资金
- National Institute of Mental Health [ZIAMH002896, ZICMH002899, R01MH110594]
- Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) ElectRx program under CMO [HR0011-16-2-0022]
Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are used routinely to assess the brain's functional organization. The mechanisms that generate and coordinate the underlying neural fluctuations are largely unknown. Here we investigate the hypothesis that the nucleus basalis of Meynert (NBM), the principal source of widespread cholinergic and GABAergic projections to the cortex, contributes critically to such activity. We reversibly inactivated two distinct sites of the NBM in macaques while measuring fMRI activity across the brain. We found that inactivation led to strong, regionalized suppression of shared or global'' signal components of cortical fluctuations ipsilateral to the injection. At the same time, the commonly studied resting-state networks retained their spatial structure under this suppression. The results indicate that the NBM contributes selectively to the global component of functional connectivity but plays little if any role in the specific correlations that define resting-state networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据