期刊
NEURON
卷 97, 期 4, 页码 898-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2017.12.044
关键词
-
资金
- French National Research Agency [ANR-10-EQPX-08 OPTOPATH, LABEX BRAIN ANR 10-LABX-43]
- Foundation for Medical Research (FRM) [DEQ20170336748]
- NRJ Foundation [R15021GG]
- European Research Council (ERC) under the European Union's Seventh Framework Program/ERC [281168]
Survival critically depends on selecting appropriate defensive or exploratory behaviors and is strongly influenced by the surrounding environment. Contextual discrimination is a fundamental process that is thought to depend on the prefrontal cortex to integrate sensory information from the environment and regulate adaptive responses to threat during uncertainty. However, the precise prefrontal circuits necessary for discriminating a previously threatening context from a neutral context remain unknown. Using a combination of single-unit recordings and optogenetic manipulations, we identified a neuronal subpopulation in the dorsal medial prefrontal cortex (dmPFC) that projects to the lateral and ventrolateral periaqueductal gray (l/vlPAG) and is selectively activated during contextual fear discrimination. Moreover, optogenetic activation and inhibition of this neuronal population promoted contextual fear discrimination and generalization, respectively. Our results identify a subpopulation of dmPFC-l/vlPAG-projecting neurons that control switching between different emotional states during contextual discrimination.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据