期刊
NEURON
卷 97, 期 6, 页码 1356-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.01.051
关键词
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资金
- National Defense Science and Engineering fellowship
- Simons foundation [348880]
- Bial Foundation [413/14]
- European Research Council Consolidator Grant [COG 617142]
- HHMI International Early Career Scientist Grant [IEC 55007415]
- ERA-Net NEURON grants
- Office of Naval Research grant [N00014-15-1-2312]
Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.
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