期刊
NEURON
卷 97, 期 1, 页码 221-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2017.11.020
关键词
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资金
- Alexander von Humboldt Foundation (Feodor Lynen Program)
- intramural fellowship from Dept. of Psychology, University of Oslo
- National Institutes of Health [R37NS21135, R01AG034570, R01AG031164, R01AG054019, RF1AG054019, R01 MH093537, F32-AG039170]
The coupled interaction between slow-wave oscillations and sleep spindles during non-rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation. However, little evidence in humans supports this theory. Moreover, whether such dynamic coupling is impaired as a consequence of brain aging in later life, contributing to cognitive and memory decline, is unknown. Combining electroencephalography (EEG), structural MRI, and sleep-dependent memory assessment, we addressed these questions in cognitively normal young and older adults. Directional cross-frequency coupling analyses demonstrated that the slow wave governs a precise temporal coordination of sleep spindles, the quality of which predicts overnight memory retention. Moreover, selective atrophy within the medial frontal cortex in older adults predicted a temporal dispersion of this slow wave-spindle coupling, impairing overnight memory consolidation and leading to forgetting. Prefrontal-dependent deficits in the spatiotemporal coordination of NREM sleep oscillations therefore represent one pathway explaining age-related memory decline.
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