期刊
NEUROLOGY
卷 90, 期 16, 页码 E1418-E1424出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000005333
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资金
- Medical Research Council UK MEG Partnership Grant [MR/K005464/1]
- National Institute for Health Research (Oxford Biomedical Research Centre based at Oxford University Hospitals Trust)
- Wellcome Trust [104369/Z/14/Z]
- Research Councils UK Digital Economy Programme (Centre for Doctoral Training in Healthcare Innovation) [EP/G036861/1]
- Wellcome Trust Senior Investigator Award [104571/Z/14/Z]
- Muscular Dystrophy Association [4365, 172123]
- ALS Association
- Kimmelman Estate
- ALS Recovery Fund
- Medical Research Council
- Motor Neurone Disease Association Lady Edith Wolfson Senior Clinical Fellowship [MR/K01014X/1]
- MRC [MR/L023784/2, MR/K01014X/1] Funding Source: UKRI
- Wellcome Trust [104369/Z/14/Z] Funding Source: Wellcome Trust
Objective We sought to assess cortical function in amyotrophic lateral sclerosis (ALS) using noninvasive neural signal recording. Methods Resting-state magnetoencephalography was used to measure power fluctuations in neuronal oscillations from distributed cortical parcels in 24 patients with ALS and 24 healthy controls. A further 9 patients with primary lateral sclerosis and a group of 15 asymptomatic carriers of genetic mutations associated with ALS were also studied. Results Increased functional connectivity, particularly from the posterior cingulate cortex, was demonstrated in both patient groups compared to healthy controls. Directionally similar patterns were also evident in the asymptomatic genetic mutation carrier group. Conclusion Increased cortical functional connectivity elevation is a quantitative marker that reflects ALS pathology across its clinical spectrum, and may develop during the presymptomatic period. The amelioration of pathologic magnetoencephalography signals might be a marker sensitive enough to provide proof-of-principle in the development of future neuroprotective therapeutics.
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