期刊
NEUROLOGICAL SCIENCES
卷 39, 期 7, 页码 1279-1282出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-018-3341-2
关键词
Dystrophinopathies; Duchenne muscular dystrophy; Autism spectrum disorder; Dystrophin; Central nervous system; Neurodevelopmental disorder
资金
- Ministry of Health, Labour and Welfare of Japan (Research Grant on Comprehensive Research on Disability Health and Welfare)
- Ministry of Health, Labour and Welfare of Japan [H26-shinkei-kin-ippan-004]
- JSPS KAKENHI [25380926, 17K14067]
- Grants-in-Aid for Scientific Research [17K14067] Funding Source: KAKEN
Recent studies have reported a higher prevalence of autism spectrum disorders among patients with dystrophinopathies. The aim of this study was to investigate the prevalence of autism spectrum disorder (ASD) among those with dystrophinopathies. The possible role of dystrophin isoforms in patients was also explored. Fifty-six patients recruited from Toneyama National Hospital were included in this study (mean age = 12.9 years, SD = 5.2 years). Autistic symptoms were evaluated using the Pervasive Developmental Disorders/Autism Spectrum Disorders Rating Scale (PARS), a clinician rating scale. Eleven patients (19.6%; 95% confidence interval 10.2-32.4) met the criteria for ASD based on their PARS scores. Patients were separated into two groups based on the cumulative loss of dystrophin isoforms predicted from the mutation location. The prevalence of ASD was examined between these groups. Infantile and current autistic symptoms did not differ between the groups, except on one subscale of the PARS. This study revealed that there was a high prevalence of ASD in patients with dystrophinopathies.
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