期刊
NEUROIMAGE
卷 182, 期 -, 页码 488-499出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2018.02.017
关键词
Neurite density; Orientation dispersion; Cortical mapping; Myeloarchitecture; Bands of baillarger
资金
- McDonnell Center for Systems Neuroscience at Washington University
- program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Japan Agency for Medical Research and development, AMED [JP17dm0207001]
- RIKEN Compass to Healthy Life Research Complex Program from Japan Science and Technology Agency, JST
- MEXT KAKENHI [16H03300, 16H03306, 16H01626, 15K12779]
- NIH [R01 MH-60974, F30 MH097312]
- [1U54MH091657]
- Grants-in-Aid for Scientific Research [16H03306, 16H03300, 15K12779, 16H01626, 15K21715] Funding Source: KAKEN
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural (T1w and T2w images) and diffusion MRI data in 505 subjects from the Human Connectome Project. Neurite distributions were evaluated using the neurite orientation dispersion and density imaging (NODDI) model, optimized for gray matter, and mapped onto the cortical surface using a method weighted towards the cortical mid-thickness to reduce partial volume effects. The estimated neurite density was high in both somatosensory and motor areas, early visual and auditory areas, and middle temporal area (MT), showing a strikingly similar distribution to myelin maps estimated from the T1w/T2w ratio. The estimated neurite orientation dispersion was particularly high in early sensory areas, which are known for dense tangential fibers and are classified as granular cortex by classical anatomists. Spatial gradients of these cortical neurite properties revealed transitions that colocalize with some areal boundaries in a recent multimodal parcellation of the human cerebral cortex, providing mutually supportive evidence. Our findings indicate that analyzing the cortical gray matter neurite morphology using diffusion MRI and NODDI provides valuable information regarding cortical microstructure that is related to but complementary to myeloarchitecture.
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