A method to detect sleep apnea based on deep neural network and hidden Markov model using single-lead ECG signal

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder that potentially threatened people's cardiovascular system. As an alternative to polysomnography for OSA detection, ECG-based methods have been developed for several years. However, previous work is focused on feature engineering, which is highly dependent on the prior knowledge of human experts and maybe subjective. Moreover, feature engineering also highlights the prominent shortcoming of current learning algorithms that the features are unable to extracted and organized from the data. In this study, we proposed a method to detect OSA based on deep neural network and Hidden Markov model (HMM) using singlelead ECG signal. The method utilized sparse auto-encoder to learn features, which belongs to unsupervised learning that only requires unlabeled ECG signals. Two types classifiers (SVM and ANN) are used to classify the features extracted from the sparse auto-encoder. Considering the temporal dependency, HMM was adopted to improve the classification accuracy. Finally, a decision fusion method is adopted to improve the classification performance. About 85% classification accuracy is achieved in the per-segment OSA detection, and the sensitivity is up to 88.9%. Based on the results of per-segment OSA detection, we perfectly separate the OSA recording from normal with accuracy of 100%. Experimental results demonstrated that our proposed method is reliable for OSA detection. (C) 2018 Elsevier B.V. All rights reserved.