期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 149, 期 -, 页码 1-9出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2018.01.010
关键词
Propranolol; Memory consolidation; Lymnaea; PTSD
资金
- Natural Sciences and Engineering Research Council of Canada [227993-2013]
- Alberta Innovates [201500755] Funding Source: researchfish
The therapeutic efficacy of the synthetic beta-adrenergic receptor blocker, propranolol, for the treatment of posttraumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the invertebrate model Lymnaea to study propranolol's ability to disrupt consolidation of memories formed under varying various types of stress which cause differing degrees of emotional memory. We show that when propranolol is administered immediately following operant conditioning, only the consolidation process of memories enhanced by individual stressors (i.e. a non-emotional memory) is susceptible to disruption. However, when propranolol is administered prior to training, only memories enhanced by a combination of stressors leading to an emotional memory are susceptible to disruption. These data suggest that the time of propranolol administration, as well as the type of memory formed play a key role in propranolol's ability to obstruct memory consolidation.
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