期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 150, 期 -, 页码 136-150出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2018.02.023
关键词
Place learning; Reversal learning; Sucrose preference; Episodic-like memory; Extinction learning; Negative emotional contrast; Social preference; Sex-difference; Mouse models of human disease
资金
- Max Planck Society
- Max Planck Forderstiftung
- DFG (CNMPB)
- EXTRABRAIN EU
- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)
- EU-AIMS
- Innovative Medicines Initiative Joint Undertaking [115300]
- European Union's Seventh Framework Programme
- EFPIA
- Autism Speaks
Based on the intellicage paradigm, we have developed a novel cognitive, emotional and social phenotyping battery that permits comprehensive standardized behavioral characterization of mice in an experimenter-independent social setting. Evaluation of this battery in a large number of male and female C57BL/6 wildtype mice, tested in > 20 independent cohorts, revealed high reproducibility of the behavioral readouts and may serve as future reference tool. We noticed robust sex-specific differences in general activity, cognitive and emotional behavior, but not regarding preference for social pheromones. Specifically, female mice revealed higher activity, decreased sucrose preference, impaired reversal and place-time-reward learning. Furthermore, female mice reacted more sensitively than males to reward-withdrawal showing a negative emotional contrast/Crespi-effect. In a series of validation experiments, we tested mice with different pathologies, including neuroligin-3 deficient mice (male nlgn3(y/-) and female NIgn3(+/-)) for autistic behavior, oligodendrocyte-specific erydu-opoietin receptor knockout (oEpoR(-/-)) mice for cognitive impairment, as well as mouse models of renal failure (unilateral ureteral obstruction and 5/6 nephrectomy) and of type 2 diabetes (ApoE(-/-)) - for delineating potentially confounding effects of motivational factors (thirst, glucose-craving) on learning and memory assessments. As prominent features, we saw in Nlgn3 mutants reduced preference for social pheromones, whereas oEpoR(-/-) mice showed learning deficits in place or reversal learning tasks. Renal failure led to increased water intake, and diabetic metabolism to enhanced glucose preference, limiting interpretation of hereon based learning and memory performance in these mice. The phenotyping battery presented here may be well-suited as high throughput multifaceted diagnostic instrument for translational neuropsychiatry and behavioral genetics.
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