期刊
NEUROBIOLOGY OF AGING
卷 61, 期 -, 页码 102-111出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.09.022
关键词
Splenectomy; Stroke; Age; Middle cerebral artery occlusion model; Immune response
资金
- AHA [16POST27490032]
- [RO1 NSO94543]
- [R21 NSO88969]
Elderly stroke patients and aged animals subjected to experimental stroke have significantly worse functional recovery and higher mortality compared to younger subjects. Activation of the peripheral immune system is known to influence stroke outcome. Prior studies have shown that splenectomy reduces ischemic brain injury in young mice. As immune function changes with aging, it is unclear whether splenectomy will confer similar benefits in aged animals. We investigated the contribution of spleen to brain injury after cerebral ischemia in aged male mice. Splenic architecture and immune cell composition were altered in aged mice. Splenectomy 2 weeks before stroke resulted in improved neurobehavioral and infarct outcomes in aged male mice. In addition, there was a reduction in peripheral immune cell infiltration into the brain and decreased levels of peripheral inflammatory cytokines after stroke in aged splenectomized mice. Splenectomy immediately after reperfusion also improved behavioral and infarct outcomes. This study suggests that inhibition of the splenic immune response is a translationally relevant target to pursue for stroke treatment in aged individuals. (C) 2017 Elsevier Inc. All rights reserved.
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