期刊
NEUROBIOLOGY OF AGING
卷 64, 期 -, 页码 25-32出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.12.006
关键词
White matter hyperintensities; Cortical thickness; Cognition; Alzheimer's disease; Memory
资金
- Washington Heights-Inwood Columbia Aging Project (WHICAP) - National Institute on Aging (NIA) [P01AG07232, R01AG037212, RF1AG054023, R01 AG034189, R01 AG054520, R56 AG034189]
- National Center for Advancing Translational Sciences, National Institutes of Health [UL1TR001873]
White matter hyperintensities (WMH) have been linked to cognitive dysfunction and dementia, although the reasons are unclear. One possibility is that WMH promote neurodegeneration, which, in turn, affects cognition. We examined whether cortical thickness, a marker of neurodegeneration, mediates the relationship between WMH and cognition among 519 older adults. Using conditional process analysis modeling techniques, we examined the association between WMH volume and global cognition and tested whether cortical thickness mediates this relationship statistically. We also tested specific regional hypotheses to determine whether cortical thickness or volume in the medial temporal lobe mediates the relationship between WMH volume and memory. Increased total WMH volume was associated with poorer global cognition and memory. Global cortical thickness and medial temporal lobe thickness/volume mediated the relationship of WMH volume on global cognition and memory functioning. The mediating relationship was similar across racial and ethnic groups and across diagnostic groups (i.e., mild cognitive impairment/Alzheimer's disease). The findings suggest that WMH promote atrophy, which, in turn, drives cognitive decline and highlight a potential pathway in which small vessel cerebrovascular disease affects cognition by promoting neurodegenerative changes directly. (C) 2017 Elsevier Inc. All rights reserved.
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