期刊
TOXICOLOGICAL RESEARCH
卷 29, 期 3, 页码 157-164出版社
KOREAN SOC TOXICOLOGY
DOI: 10.5487/TR.2013.29.3.157
关键词
Ischemic stroke; Blood-brain barrier; Tight junction; Neurovascular unit; Heavy metals
类别
资金
- Korea Foundation for the Advancement of Science & Creativity (KOFAC) 2012 URP grant - Korean Government (MEST)
Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.
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