期刊
EMERGING INFECTIOUS DISEASES
卷 19, 期 9, 页码 1385-1392出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1909.130682
关键词
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资金
- Blood Systems Research Institute
- National Institutes of Health [R01 HL105770]
- Bernice Barbour Foundation
- University of Cantornia, Davis, Center for Companion Animal Health
Using viral metagenomics of brain tissue from a young adult crossbreed steer with acute onset of neurologic disease, we sequenced the complete genome of a novel astrovirus (BoAstV-NeuroS1) that was phylogenetically related to an ovine astrovirus. In a retrospective analysis of 32 cases of bovine encephalitides of unknown etiology, 3 other infected animals were detected by using FOR and in situ hybridization for viral RNA. Viral RNA was restricted to the nervous system and detected in the cytoplasm of affected neurons within the spinal cord, brainstem, and cerebellum. Microscopically, the lesions were of widespread neuronal necrosis, microgliosis, and perivascular cuffing preferentially distributed in gray matter and most severe in the cerebellum and brainstem, with increasing intensity caudally down the spinal cord. These results suggest that infection with BoAstV-NeuroS1 is a potential cause of neurologic disease in cattle.
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