期刊
CURRENT BREAST CANCER REPORTS
卷 5, 期 3, 页码 208-221出版社
SPRINGER
DOI: 10.1007/s12609-013-0114-z
关键词
Alcohol; Alcohol dehydrogenase (ADH); BRCA1; BRCA2; Breast cancer; Mammographic density; Risk; Prevention; Screening; Review
类别
资金
- NCI NIH HHS [T32 CA009529] Funding Source: Medline
Moderate alcohol consumption has been linked to an approximate 30 %-50 % increased risk in breast cancer. Case-control and cohort studies have consistently observed this modest increase. We highlight recent evidence from molecular epidemiologic studies and studies of intermediate markers like mammographic density that provide additional evidence that this association is real and not solely explained by factors/correlates of the exposure and outcome present in nonrandomized studies. We also review evidence from studies of higher risk women including BRCA1 and BRCA2 mutation carriers. Given the incidence of heart disease is higher than breast cancer and modest alcohol consumption is associated with reduced risk of heart disease, we examine the latest evidence to evaluate if alcohol reduction should be targeted to women at high risk for breast cancer. We also review the most recent evidence on the effect of alcohol use on tumor recurrence and survival for those diagnosed with breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据