期刊
NEURAL REGENERATION RESEARCH
卷 13, 期 2, 页码 194-197出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.226382
关键词
oxygen consumption; bioenergetics; oxidative phosphorylation; cellular uptake; replacement strategies; spinal cord injury; mitochondria
资金
- NIH [R21NS096670]
- University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment
- NIH/NINDS [2P30NS051220]
Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of mitochondrial medicine is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.
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