期刊
NEURAL REGENERATION RESEARCH
卷 13, 期 3, 页码 492-496出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.228733
关键词
nerve regeneration; ischemic postconditioning; nerve injury; insulin-like growth factor 1; sciatic nerve; ischemia/reperfusion; neural regeneration
资金
- Beijing Municipal Natural Science Foundation (CN) [71520061]
- Beijing Municipal Science and Technology Commission, China [Z161100000116080]
Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.
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