期刊
PATHOGENS
卷 2, 期 3, 页码 436-445出版社
MDPI AG
DOI: 10.3390/pathogens2030436
关键词
prion; Prnp-deficient; prion diseases; autophagy; autophagic flux; oxidative stress
类别
资金
- National Research Foundation of Korea Grant - Korean Government [NRF-2011-619-E0001]
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012-0000308]
Cellular prion protein (PrPC) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrPC.
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